G protein‐coupled receptors (GPCRs) are the largest family of transmembrane receptors and primarily signal through two main effector proteins: G proteins and β‐arrestins. Many agonists of GPCRs promote “biased” responses, in which different cellular signaling pathways are activated with varying efficacies. The mechanisms underlying biased signaling have not been fully elucidated, with many potential “hidden variables” that regulate this behavior. One contributor is “location bias,” which refers to the generation of unique signaling cascades from a given GPCR depending upon the (...) cellular location at which the receptor is signaling. Here, we review evidence that GPCRs are expressed at and traffic to various subcellular locations and discuss how location bias can impact the pharmacologic properties and characterization of GPCR agonists. We also evaluate how differences in subcellular environments can modulate GPCR signaling, highlight the physiological significance of subcellular GPCR signaling, and discuss the therapeutic potential of exploiting GPCR location bias. (shrink)

Epistemologists have a special fondness for David Hume. Even Kant-obsessed a priorists admire the honesty, directness and elegance of his thinking. He is the Mozart of analytic philosophy rather than the Bach. Sparkling ideas, icy clarity and popular delivery make his writings the standard for good philosophy. 'Try to think like Hume' is pretty decent advice. But is that his only use today—to be emulated in style and approach? This volume is a collective 'no'. A team of top epistemologists and (...) historians join forces to demonstrate the relevance of Humean ideas to the most current questions and debates. Hume dribbles into the following themes, much to the advantage of each: knowledge, belief, inquiry and suspension, reason and reasons, scepticism, hinge epistemology, naturalized epistemology, the ethics of belief and moral epistemology, virtue and vice epistemology, the epistemology of testimony. Epistemologists who discount history and historians who halt at 1950 should gallop to this volume and start reading. Neither perspective will survive. (shrink)

This book analyses the straw man fallacy and its deployment in philosophical reasoning. While commonly invoked in both academic dialogue and public discourse, it has not until now received the attention it deserves as a rhetorical device. Scott Aikin and John Casey propose that straw manning essentially consists in expressing distorted representations of one's critical interlocutor. To this end, the straw man comprises three dialectical forms, and not only the one that is usually suggested: the straw man, the weak (...) man and the hollow man. Moreover, they demonstrate that straw manning is unique among fallacies as it has no particular logical form in itself, because it is an instance of inappropriate meta-argument, or argument about arguments. They discuss the importance of the onlooking audience to the successful deployment of the straw man, reasoning that the existence of an audience complicates the dialectical boundaries of argument. Providing a lively, provocative and thorough analysis of the straw man fallacy, this book will appeal to postgraduates and researchers alike, working in a range of fields including fallacies, rhetoric, argumentation theory and informal logic. (shrink)

For anyone approaching the Encheiridion of Epictetus for the first time, this book provides a comprehensive guide to understanding a complex philosophical text. Including a full translation and clear explanatory commentaries, Epictetus's 'Encheiridion' introduces readers to a hugely influential work of Stoic philosophy. Scott Aikin and William O. Stephens unravel the core themes of Stoic ethics found within this ancient handbook. Focusing on the core themes of self-control, seeing things as they are, living according to nature, owning one's roles (...) and fulfilling the responsibilities that those roles entail, the authors elucidate the extremely challenging ideas in Epictetus's brisk chapters. Divided into five distinct parts, this book provides readers with: -/- - A new translation of the Encheiridion by William O. Stephens. - A new introduction to ancient Stoicism, its system of concepts, and the ancient figures who shaped it. - A fresh treatment of the notorious and counter-intuitive 'Stoic paradoxes'. - An accessible overview of the origin and historical context of the Encheiridion. - Detailed commentaries on each chapter of the Encheiridion that clarify its recurring themes and highlight their interconnections. - Careful attention to the presentation of the arguments embedded in Epictetus's aphoristic style. - A thoughtful discussion of serious criticisms of Epictetus's Stoicism and replies to these objections. -/- Written with clarity and authority, Epictetus's 'Encheiridion' provides a foundation from which readers can understand this important text and engage with the fundamental questions of Stoic philosophy and ethics. This guide will aid teachers of Epictetus, students encountering Stoicism for the first time, and readers seeking a greater understanding of Stoic ethics. (shrink)

In the last decade, the familiar problem of the regress of reasons has returned to prominent consideration in epistemology. And with the return of the problem, evaluation of the options available for its solution is begun anew. Reason’s regress problem, roughly put, is that if one has good reasons to believe something, one must have good reason to hold those reasons are good. And for those reasons, one must have further reasons to hold they are good, and so a regress (...) of reasons looms. In this new study, Aikin presents a full case for infinitism as a response to the problem of the regress of reasons. Infinitism is the view that one must have a non-terminating chain of reasons in order to be justified. The most defensible form of infinitism, he argues, is that of a mixed theory – that is, epistemic infinitism must be consistent with and integrate other solutions to the regress problem. (shrink)

Scientistic conceptualisations hold to the positivistic positions that science is limitless in its potential representations of material phenomena and that it is the only sure path to knowledge. In recent popular scientific literature, these presuppositions have been reaffirmed to the detriment of both philosophy and theology. This article argues for the contrary position by a meta-analysis of empirical science from a Thomist perspective. Identifying empirical science as limited in its method and bound to the material sphere of being alone, we (...) posit that rather than standing as the sole path to the knowledge of being, empirical science is constrained at its frontiers. It is subsequently contended that far from empirical science having the explanatory ability to respond to all presenting scientific problems in principle, fundamentals without the grasp of the methodology of empirical science exist. To relate the article’s meta-analysis to scientific praxis, physical cosmology – as the most foundational empirical science – is exemplified in the discussion.Keywords: Philosophy; Religion; Science; Scientism; Thomism; Metaphysics; Epistemology. (shrink)

Inspired by a debate between Noam Chomsky and Jean Piaget, this work traces the development of natural history from Aristotle to Darwin, and demonstrates how the science of plants and animals has emerged from the common conceptions of folkbiology.

An examination of the history and arguments behind W.K. Clifford and William James's landmark essays and subsequent impact on the importance of knowledge-based evidence.

What follows is a taxonomy of arguments that regresses of inferential justification are vicious. They fall out into four general classes: conceptual arguments from incompleteness, conceptual arguments from arbitrariness, ought-implies-can arguments from human quantitative incapacities, and ought-implies can arguments from human qualitative incapacities. They fail with a developed theory of "infinitism" consistent with valuational pluralism and modest epistemic foundationalism.

Free speech fallacies are errors of meta-argument. One commits a free speech fallacy when one argues that since there are apparent restrictions on one’s rights of free expression, procedural rules of critical exchange have been broken, and consequently, one’s preferred view is dialectically better off than it may otherwise seem. Free speech fallacies are meta-argumentative, since they occur at the level of assessing the dialectical situation in terms of norms of argument and in terms of meta-evidential principles of interpreting how (...) and why people follow (or fail to follow) argumentative rules. Our plan here is to begin with a brief explanation of meta-argument and meta-argumentative fallacy. We will then turn to the variety of forms of the free speech fallacy, which we will explain as meta-argumentatively erroneous. (shrink)

Arguments are weakly meta-argumentative when they call attention to themselves and purport to be successful as arguments. Arguments are strongly metaargumentative when they take arguments (themselves or other arguments) as objects for evaluation, clarification, or improvement and explicitly use concepts of argument analysis for the task. The ambitious meta-argumentation thesis is that all argumentation is weakly argumentative. The modest meta-argumentation thesis is that there are unique instances of strongly meta-argumentative argument. Here, we show how the two theses are connected and (...) both are plausible. (shrink)

Part one attempts to diffuse five different forms of truth skepticism, broadly conceived: the view that truth is indefinable, that it is unknowable, that it is inextricably metaphysical, that there is no such thing as truth, and the view that truth is inherently paradoxical, and so must either be abandoned, or revised. An intriguing formulation of the last of these views is due to Alfred Tarski, who argued that the Liar paradox shows natural languages to be inconsistent because they contain (...) defective, and ultimately incoherent, truth predicates. I argue in response that on a plausible interpretation of his puzzling notion of an inconsistent language, Tarski’s argument turns out to be logically valid, but almost certainly unsound, since one of its premises can be seen to be indefensible. Similar results are achieved for other forms of truth skepticism. (shrink)

Positive psychology is an approach to psychology that focuses on the utilization of strengths, positive emotions, well-being, and personal growth to help individuals thrive, flourish, and achieve optimal functioning. The following case study highlights how positive psychology theories and techniques, specifically strengths-development and gratitude interventions, were implemented into a sport psychology intervention by a trainee sport and exercise psychologist. It is hoped that other practitioners may find the case study a useful insight into how they may be able to incorporate (...) positive psychology into their practice. (shrink)

Anti-individualism is the thesis that features of the social and physical environments contribute to determining the contents of our beliefs. The notion of content implicit in the thought experiments supporting anti-individualism is tied to explications of how our terms and the concepts they express are correctly applied. Since anti-individualists should regard these explications as a subject of ongoing dispute, they should claim that sameness and difference of content is not always detectable upon reflection. Many philosophers accordingly worry that anti-individualists cannot (...) accommodate the use of belief attributions to characterize individual points of view. The key to these objections is the thesis that belief attributions have the same truth-value if they attribute beliefs with the same content. When the semantic and metaphysical motivations for this assumption are discredited, anti-individualism's alleged problems with characterizing individual points of view may be solved without introducing an additional notion of "cognitive" content which tracks differential dubitability judgments. The resulting account of belief requires a new account of understanding and responsibility to evaluation which emphasizes participation in ongoing attempts to formulate explications rather than knowledge thereof. (shrink)

"One of the most profound and illuminating studies of this century to have been published in recent decades."--John Gray, New York Times Book Review Hailed as "a magisterial critique of top-down social planning" by the New York Times, this essential work analyzes disasters from Russia to Tanzania to uncover why states so often fail--sometimes catastrophically--in grand efforts to engineer their society or their environment, and uncovers the conditions common to all such planning disasters. "Beautifully written, this book calls into sharp (...) relief the nature of the world we now inhabit."--New Yorker "A tour de force."-- Charles Tilly, Columbia University. (shrink)

Scholars in philosophy, political science, and the policy community have recently advocated for a ‘sticks and carrots’, or conditional-coercion, approach to human rights violations. On this model, rights violators (usually states) are conceived of as rational agents who should be rewarded for good behavior and punished for bad behavior by other states seeking to improve human rights abroad. External states concerned about human rights abroad should impose punishments against foreign rights violators, and these punitive measures should not be lifted until (...) rights violations in target countries cease. Against these scholars, I argue that the conditional-coercion model is mistaken. In this article, I explicate the ‘sticks and carrots’ approach to human rights, criticize it on both theoretical and empirical grounds, and suggest an alternative approach that I term rights diagnostics. The model I propose is sensitive to the internal political struggles in rights violating states and the incentive structures faced by rights violators. This model takes account of relevant empirical evidence on the role of external coercion and inducements in producing institutional change. I conclude by sketching an institutional design that would potentially implement ‘rights diagnostics’ policy.1. (shrink)

What is morality? How many moral values are there? And what are they? According to the theory of morality-as-cooperation, morality is a collection of biological and cultural solutions to the problems of cooperation recurrent in human social life. This theory predicts that there will be as many different types of morality as there are different types of cooperation. Previous research, drawing on evolutionary game theory, has identified at least seven different types of cooperation, and used them to explain seven different (...) types of morality: family values, group loyalty, reciprocity, heroism, deference, fairness and property rights. Here we explore the conjecture that these simple moral ‘elements’ combine to form a much larger number of more complex moral ‘molecules’, and that as such morality is a combinatorial system. For each combination of two elements, we hypothesise a candidate moral molecule, and successfully locate an example of it in the professional and popular literature. These molecules include: fraternity, blood revenge, family pride, filial piety, gavelkind, primogeniture, friendship, patriotism, tribute, diplomacy, common ownership, honour, confession, turn taking, restitution, modesty, mercy, munificence, arbitration, mendicancy, and queuing. These findings indicate that morality – like many other physical, biological, psychological and cultural systems – is indeed a combinatorial system. Thus morality-as-cooperation provides a principled and powerful theory, that explains why there are many moral values, and successfully predicts what they will be; and it generates a systematic framework that has the potential to explain all moral ideas, possible and actual. Pursuing the many implications of this theory will help to place the study of morality on a more secure scientific footing. (shrink)

This essay assesses the rationale for regulating research administrators as carefully as they regulate researchers. The reasons for such regulation are identical: protecting scientific integrity, ensuring responsible use of public funds, addressing the lack of effective recourse for victims, creating negative consequences for misbehaving actors, and addressing high incentives for misconduct. Whereas the reasons compelling us to regulate research administrators are obvious, counterarguments to administrative oversight are based on suggestions that the incidence and prevalence of cases of administrative misconduct are (...) too low to warrant formal regulation. I briefly describe examples of the phenomenon drawn from publicly available records. My analysis suggests that the misconduct of research administrators is both serious and worthy of better oversight. Improved oversight of research administration will help steward tax dollars appropriately and enhance the overall integrity of the scientific record and of the free pursuit of knowledge more generally. (shrink)

There is a section in Samuel Delany’s magnificent autobiographical meditation, The Motion of Light in Water, that dramatically raises the problem of writing the history of difference, the history, that is, of the designation of “other,” of the attribution of characteristics that distinguish categories of people from some presumed norm.1 Delany recounts his reaction to his first visit to the St. Marks bathhouse in 1963. He remembers standing on the threshold of a “gym-sized room” dimly lit by blue bulbs. The (...) room was full of people, some standing, the rest an undulating mass of naked, male bodies, spread wall to wall. My first response was a kind of heart-thudding astonishment very close to fear. I have written of a space at certain libidinal saturation before. That was not what frightened me. It was rather that the saturation was not only kinesthetic but visible.2Watching the scene establishes for Delany a “fact that flew in the face” of the prevailing representation of homosexuals in the 1950s as “isolated perverts,” as subjects “gone awry.” The “apprehension of massed bodies” gave him a “sense of political power”:what this experience said was that there was a population—not of individual homosexuals … not of hundreds, not of thousands, but rather of millions of gay men, and that history had, actively and already, created for us whole galleries of institutions, good and bad, to accommodate our sex. [M, p. 174] 2. Samuel R. Delany, The Motion of Light in Water: Sex and Science Fiction Writing in the East Village, 1957-1965 , p. 173; hereafter abbreviated M. Joan W. Scott is professor of social science at the Institute for Advanced Study in Princeton, New Jersey. She is the author, most recently, of Gender and the Politics of History and is currently at work on a history of feminist claims for political rights in France during the period 1789-1945 as a way of exploring arguments about equality and difference. (shrink)

Given immunity’s general role in the organism’s economy—both in terms of its internal environment as well as mediating its external relations—immune theory has expanded its traditional formulation of preserving individual autonomy to one that includes accounting for nutritional processes and symbiotic relationships that require immune tolerance. When such a full ecological alignment is adopted, the immune system becomes the mediator of both defensive and assimilative environmental intercourse, where a balance of immune rejection and tolerance governs the complex interactions of the (...) organism’s ecological relationships. Accordingly, immunology, which historically had affiliated with the biology of individuals, now becomes a science concerned with the biology of communities. With this translocation, the ontological basis of the organism is undergoing a profound change. Indeed, the recent recognition of the ubiquity of symbiosis has challenged the traditional notions of biological individuality and requires a shift in the metaphysics undergirding biology, in which a philosophy of the organism must be characterized by ecological dialectics “all-the-way-down.”. (shrink)

This article presents the results of a study that investigated the roles that one's money ethic, religiosity and attitude toward business play in determining consumer attitudes/beliefs in various situations regarding questionable consumer practices. Two dimensions of religiosity - intrinsic and extrinsic religiousness - were studied. A global scale of money ethic was examined, as was a global measure of attitude toward business. Results indicate that both types of religiosity as well as one's money ethic and attitude toward business were significant (...) determinants of at least some types of consumer ethical beliefs. (shrink)

The straw man fallacy consists in inappropriately constructing or selecting weak versions of the opposition's arguments. We will survey the three forms of straw men recognized in the literature, the straw, weak, and hollow man. We will then make the case that there are examples of inappropriately reconstructing stronger versions of the opposition's arguments. Such cases we will call iron man fallacies.

Contemporary suicide terrorists from the Middle East are publicly deemed crazed cowards bent on senseless destruction who thrive in poverty and ignorance. Recent research indicates they have no appreciable psychopathology and are as educated and economically well-off as surrounding populations. A first line of defense is to get the communities from which suicide attackers stem to stop the attacks by learning how to minimize the receptivity of mostly ordinary people to recruiting organizations.

The present study uses cross‐cultural samples of marketing practitioners from two European Union (EU) nations (the United Kingdom and Spain) and China to examine the relationships between moral intensity, personal moral philosophies and ethical decision making. Additionally, cross‐cultural comparisons were made regarding intentions, personal moral philosophies and moral intensity. Results indicate that both samples tend to use the perceived harm construct (e.g. magnitude of consequences, probability of effect, temporal immediacy and concentration of effect) to determine intentions in situations involving ethical (...) issues. However, social consensus tends to be situation‐specific for both groups and proximity seems not to be used at all when making decisions in situations involving ethics. As for personal moral philosophies, idealism is only used by the EU sample; however, for both samples, the use of relativism depends upon the specific situation. (shrink)

Sacred values differ from material or instrumental values in that they incorporate moral beliefs that drive action in ways dissociated from prospects for success. Across the world, people believe that devotion to essential or core values – such as the welfare of their family and country, or their commitment to religion, honor, and justice – are, or ought to be, absolute and inviolable. Counterintuitively, understanding an opponent's sacred values, we believe, offers surprising opportunities for breakthroughs to peace. Because of the (...) emotional unwillingness of those in conflict situations to negotiate sacred values, conventional wisdom suggests that negotiators should either leave sacred values for last in political negotiations or try to bypass them with sufficient material incentives. Our empirical findings and historical analysis suggest that conventional wisdom is wrong. In fact, offering to provide material benefits in exchange for giving up a sacred value actually makes settlement more difficult because people see the offering as an insult rather than a compromise. But we also found that making symbolic concessions of no apparent material benefit might open the way to resolving seemingly irresolvable conflicts. We offer suggestions for how negotiators can reframe their position by demonstrating respect, and/or by apologizing for what they sincerely regret. We also offer suggestions for how to overcome sacred barriers by refining sacred values to exclude outmoded claims, exploiting the inevitable ambiguity of sacred values, shifting the context, provisionally prioritizing values, and reframing responsibility. (shrink)

There has been a promising discussion brewing recently about whether there is an ethics of inquiry—that is, a unique set of ethical rules that constrains inquirers specifically in their role as inquirers. Most prominently, Philip Kitcher has proposed that there is indeed an ethics of inquiry. He argues that, given the intellectual climate of many modern societies, certain research programs are likely to encourage further social injustice against members of already disadvantaged groups; in such cases, inquirers are obligated to refrain (...) from that research, regardless of its expected or likely results. Kitcher has in mind scientific research regarding the natural capacities of members of traditionally underprivileged social groups; he thinks that, given the degree of prejudice and discrimination that obtains in many societies, research into the possibility of a biological basis for differences in accomplishment among different races and sexes should be prohibited, even where the proposed research promises to debunk racist and sexist views. (shrink)

Entry in International Encyclopedia of Ethics on Ethical considerations bearing on Argumentation.

Studies of the Early Modern debate concerning absolute and relative space and motion often ignore the significance of the concept of true motion in this debate. Even philosophers who denied the existence of absolute space maintained that true motions could be distinguished from merely apparent ones. In this paper, I examine Berkeley's endorsement of this distinction and the problems it raises. First, Berkeley's endorsement raises a problem of consistency with his other philosophical commitments, namely his idealism. Second, Berkeley's endorsement raises (...) a problem of adequacy, namely whether Berkeley can provide an adequate account of what grounds the distinction between true and merely apparent motion. In this paper, I argue that sensitivity to Berkeley's distinction between what is true in the metaphysical, scientific, and vulgar domains can address both the consistency and the adequacy problems. I argue that Berkeley only accepts true motion in the scientific and vulgar domains, and not the metaphysical. There is thus no inconsistency between his endorsement of true motion in science and ordinary language, and his metaphysical idealism. Further, I suggest that sensitivity to these three domains shows that Berkeley possesses resources to give an adequate account of how true motions are discovered in natural science. (shrink)

There is a wealth of evidence which indicates that arguments are not very efficient tools for changing minds. Against this skepticism, Novaes (2023) presents evidence that, given the right social context, arguments sometimes play a significant role in belief revision. However, drawing on Levy (2021), I argue that the evidence Novaes cites is compatible with the view that it is not arguments that change individual minds but instead belief outsourcing that occurs alongside the consideration of arguments.

Presents wide-ranging and up-to-date interpretations of the Zhuangzi, the Daoist classic and one of the most elusive works ever written.

Ralph Johnson has proposed a “two tiered” conception of argument, comprising of the illative core and the dialectical tier. This paper's two-part thesis is that (i) the dialectical tier is best understood as an epistemic requirement for argument, and (ii) once understood epistemically, the dialectical tier requirement can be defended against the leading objections.

Resolution of quarrels arising from conflicting sacred values, as in the Middle East, may require concessions that acknowledge the opposition's core concerns.

As one component of a broader social and normative response to the problem of suicide, scientism served to minimize sociopolitical and religious conflict around the issue. As such, it embodied, and continues to embody, a number of interests and values, as well as serving important social functions. It is thus comparable with other normative frameworks and can be appraised, from an ethical perspective, in light of these values, interests, and functions. This work examines the key values, interests, and functions of (...) scientism in suicidology and argues that although scientism has had some social benefit, it primarily serves to maintain political and professional interests and has damaging implications for suicide research and prevention. (shrink)

The Routledge Companion to Pragmatism offers 44 cutting-edge chapters--written specifically for this volume by an international team of distinguished researchers--that assess the past, present, and future of pragmatism. Going beyond the exposition of canonical texts and figures, the collection presents pragmatism as a living philosophical idiom that continues to devise promising theses in contemporary debates. The chapters are organized into four major parts: Pragmatism's History and Figures Pragmatism and Plural Traditions Pragmatism's Reach Pragmatism's Relevance Each chapter provides up-to-date research tools (...) for philosophers, students, and others who wish to locate pragmatist options in their contemporary research fields. As a whole, the volume demonstrates that the vitality of pragmatism lies in its ability to build upon, and transcend, the ideas and arguments of its founders. When seen in its full diversity, pragmatism emerges as one of the most successful and influential philosophical movements in Western philosophy. (shrink)

His first point is that true exhibits pathologies that smidget doesn’t. If smidget is undefined for Charlie, then the sentence Charlie is a smidget is undefined, and there is no basis for accepting either it or its negation. There is no pathology here; it is simply a case in which a sentence and its negation must both be rejected. With smidget there is no paradoxicality analogous to Liar sentences and no circularity corresponding to Truth Tellers. Gupta concludes that true and (...) smidget must be very different. (shrink)

Anthropological inquiry suggests that all societies classify animals and plants in similar ways. Paradoxically, in the same cultures that have seen large advances in biological science, citizenry's practical knowledge of nature has dramatically diminished. Here we describe historical, cross-cultural and developmental research on how people ordinarily conceptualize organic nature, concentrating on cognitive consequences associated with knowledge devolution. We show that results on psychological studies of categorization and reasoning from “standard populations” fail to generalize to humanity at large. Usual populations have (...) impoverished experience with nature, which yields misleading results about knowledge acquisition and the ontogenetic relationship between folkbiology and folkpsychology. We also show that groups living in the same habitat can manifest strikingly distinct behaviors, cognitions and social relations relative to it. This has novel implications for environmental decision making and management, including commons problems. (shrink)